反应详情

温度

40 °C

Next, a reaction flask was loaded with 2-fluoro-6-(4-trifluoromethylphenoxy)pyridine (8.0 g) and ethanol (60 ml), and heated up to 40° C. with stirring. To this mixture, hydrazine monohydrate (7.6 g) was dropwise added in 30 minutes. The temperature of the mixture was raised to the reflux temperature, followed by stirring for 20 hours. Thereafter, the heating was stopped, and the reaction mixture was cooled, followed by filtration to remove insoluble components. The filtrate was condensed by an evaporator to give 2-hydrazino-6-(4-trifluoromethylphenoxy)pyridine (4.0 g).

1. temperatureThe temperature of the mixture was raised to the reflux temperature
2. stirringby stirring for 20 hours
3. temperaturethe reaction mixture was cooled
4. filtrationfollowed by filtration
5. customto remove insoluble components
6. customcondensed
7. customby an evaporator