反应详情

Next, a reaction flask was loaded with 2-fluoro-6-(2,2,3,3,4,4,5,5-octafluoropentyloxy)pyridine (10 g) and ethanol (8 ml), followed by dropwise addition of a mixture of hydrazine monohydrate (7.7 g) and ethanol (8 ml) to the flask in 30 minutes with stirring. After the dropwise addition was ended, stirring was continued at 55 to 65° C. for one hour. The heating was stopped, and water was added to the reaction mixture, followed by extraction with ethyl acetate. The extract was condensed to give 2-hydrazino-6-(2,2,3,3,4,4,5,5-octafluoropentyloxy)pyridine (10 g).

1. additionAfter the dropwise addition
2. stirringstirring
3. extractionfollowed by extraction with ethyl acetate
4. customcondensed