Hydrazine hydrate (1:1) → HCID 18544800, compound

HRID 1266928Notes

Reaction equation

HRID 1266928 reaction equation
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[C:6]([O:12][CH3:13])[N:5]=[C:4]([CH3:14])[N:3]=1.O.[NH2:16][NH2:17]>C(O)C>[NH:16]([C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[C:6]([O:12][CH3:13])[N:5]=[C:4]([CH3:14])[N:3]=1)[NH2:17]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 133793024-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine

Product 1

HCID 18544800HCID 18544800, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Next, a reaction flask was loaded with 4-fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)-pyrimidine (22 g) and ethanol (40 ml), followed by dropwise addition of hydrazine monohydrate (10.5 g) to the flask in one hour with stirring. Then, after stirring for one hour, the reaction mixture was filtrated to give 4-hydrazino-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine. By GC/MS analysis, a molecular ion peak of 222 was confirmed for this compound.

Workup

  1. stirringThen, after stirring for one hour
  2. filtrationthe reaction mixture was filtrated

Sources & evidence

ORD record
ord-ef40c0aa281a4cbc8861ef1eea4bd4f1
Source dataset
uspto-grants-2003_04
Patent number
US06551682B1

Reaction notes

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