Imidazole → HCID 12786182, compound

HRID 126693Notes

Reaction equation

HRID 126693 reaction equation
[OH:1][CH:2]([C:6](=[CH2:10])[CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.[CH2:16]([Si:18]([CH2:22][CH3:23])([CH2:20][CH3:21])Cl)[CH3:17].O>CN(C)C=O>[CH2:10]=[C:6]([CH2:7][CH2:8][CH3:9])[CH:2]([O:1][Si:18]([CH2:22][CH3:23])([CH2:20][CH3:21])[CH2:16][CH3:17])[CH2:3][C:4]#[CH:5]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 962WaterHCID 13819ChlorotriethylsilaneHCID 20565008HCID 20565008, compound

Product 1

HCID 12786182HCID 12786182, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 30.0 g. of 4-hydroxy-5-methylene-1-octyne and 31.02 g. of imidazole in 80 ml of dimethylformamide at 0° C., is added 40.9 g. of triethychlorosilane. The mixture is stirred at room temperature for 30 minutes, poured into cold water and extracted with petroleum ether. The petroleum ether is removed and the residue is distilled. The product is recovered in the fraction boiling at 103°-106° C. (1.5 mm.).

Workup

  1. extractionextracted with petroleum ether
  2. customThe petroleum ether is removed
  3. distillationthe residue is distilled
  4. customThe product is recovered in the fraction boiling at 103°-106° C. (1.5 mm.)

Sources & evidence

ORD record
ord-5b1fa5e054e949709e7017e3fcffa049
Source dataset
uspto-grants-1981_03
Patent number
US04254036

Reaction notes

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