Hydrazine hydrate (1:1) → 3,5-Dichloro-2-hydrazinylpyridine

HRID 1266936Notes

Reaction equation

HRID 1266936 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[Cl:8][C:7]1[C:2]([NH:11][NH2:12])=[N:3][CH:4]=[C:5]([Cl:9])[CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27666Pyridine, 2,3,5-trichloro-

Product 1

HCID 6009663,5-Dichloro-2-hydrazinylpyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A reaction flask was loaded with 2,3,5-trichloropyridine (11.2 g) and ethanol (12 ml), followed by dropwise addition of hydrazine monohydrate. (9.2 g) to the flask in one hour with stirring. After stirring overnight, the reaction mixture was filtrated and the filtrate was condensed to precipitate crystals. The crystals were filtrated for collection and air-dried to give 3,5-dichloro-2-hydrazinopyridine (9.0 g).

Workup

  1. stirringAfter stirring overnight
  2. filtrationthe reaction mixture was filtrated
  3. customcondensed
  4. customto precipitate crystals
  5. filtrationThe crystals were filtrated for collection
  6. customair-dried

Sources & evidence

ORD record
ord-05a8a1f2438141b59c94f3198db77463
Source dataset
uspto-grants-2003_04
Patent number
US06551682B1

Reaction notes

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