反应详情

温度

70 °C

Sodium (8.1 g, 338 mmol) was added to ethanol (200 ml). After complete reaction, the excess of ethanol was evaporated. 3,5-Dichloropyridine (40.0 g, 270 mmol) and dimethyl sulfoxide (300 ml) were added to the crude mixture. The mixture was stirred at 70° C. for 1 h. Water (500 ml) was added, followed by extraction twice with ethyl acetate (300 ml). The product was isolated in quantitative yield.

1. customAfter complete reaction
2. customthe excess of ethanol was evaporated
3. extractionfollowed by extraction twice with ethyl acetate (300 ml)
4. customThe product was isolated in quantitative yield