反应详情

To a stirred solution of 4′-trifluoromethyl-biphenyl-2-carboxylic acid (4-piperazin-1-yl-phenyl)-amide (0.318 g) in CH2Cl2 (15 mL) containing Et3N (79 mg) was added dropwise 3-cyano-benzoyl chloride (0.129 g) and the mixture was stirred at room temperature for 1 hour. The solution was then washed with water, with brine, dried over Na2SO4, filtered and evaporated. The residue was then purified by flash chromatography eluting with CH2Cl2/AcOEt (80/20) and the solid obtained was recrystallized from AcOEt to give the title compound (0.29 g) as white crystals.

1. washThe solution was then washed with water, with brine
2. dry with materialdried over Na2SO4
3. filtrationfiltered
4. customevaporated
5. customThe residue was then purified by flash chromatography
6. washeluting with CH2Cl2/AcOEt (80/20)
7. customthe solid obtained
8. customwas recrystallized from AcOEt