Acetonitrile → HCID 9794302, compound

HRID 1267233Notes

Reaction equation

[C:1](Cl)(=[O:5])[C:2](Cl)=[O:3].[N:7]1([CH:15]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:14]CCCCCN1.C(#[N:25])C>>[CH2:22]([CH:15]1[N:7]2[C:1](=[O:5])[C:2](=[O:3])[N:25]=[C:14]2[CH2:17][CH2:16]1)[CH2:21][CH2:20][CH2:19][CH3:18]

Participants

Reactant 3

HCID 6342Acetonitrile

HCID 65578Oxalyl chloride

HCID 66583054Diazabicyclooctane

Product 1

HCID 9794302HCID 9794302, compound

Procedure

Ex-31) The product of Example 31d is treated with oxalyl chloride and diazabicyclooctane in acetonitrile to give the title compound, which is purified by partition between water and EtOAc, and passage over a silica column.

Sources & evidence

ORD record: ord-d8417126a04e4407ace2d0d9a2ce17a1
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06552052B2

Reaction notes

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