反应详情

To a stirred mixture of 8.5 g. of 4-trimethylsilylethynyl-1-octyn-4-ol and 6.2 g. of imidazole in 24 ml. of dry dimethylformamide is added, under nitrogen, 5.7 ml. of chlorotrimethylsilane, in a slow stream, via a syringe. The mixture is stirred in an ice-bath for one hour and then at room temperature overnight. The mixture is poured into hexane, washed with saturated sodium bicarbonate solution, water and then brine and dried over sodium sulfate. The solvents are evaporated to dryness giving 11.1 g. of the desired product.

1. additionTo a stirred mixture of 8.5 g
2. customat room temperature
3. customovernight
4. washwashed with saturated sodium bicarbonate solution, water
5. dry with materialbrine and dried over sodium sulfate
6. customThe solvents are evaporated to dryness
7. customgiving 11.1 g