Benzaldehyde → HCID 22558189, compound

HRID 1267264Notes

Reaction equation

HRID 1267264 reaction equation
[NH2:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]3)[O:8][C:4]=2[CH:3]=1.[CH:19](=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[CH:19](=[N:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]2[N:6]=[C:7]([N:9]3[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]3)[O:8][C:4]=2[CH:3]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 12016519HCID 12016519, compound

Product 1

HCID 22558189HCID 22558189, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 30 mg portion of 6-amino-5-chloro-2-(4-methyl-1-piperazinyl)benzoxazole was dissolved in 20 ml of anhydrous toluene, and the solution was mixed with 1 ml of benzaldehyde and heated under reflux for 6 hours. The solvent was concentrated under a reduced pressure, the residual oily matter was mixed with hexane and then the thus formed precipitate was collected by filtration to obtain the title compound (24 mg) in white color.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 6 hours
  3. concentrationThe solvent was concentrated under a reduced pressure
  4. additionthe residual oily matter was mixed with hexane
  5. filtrationthe thus formed precipitate was collected by filtration

Sources & evidence

ORD record
ord-a75e95265cc54ceb96a78df4c437798c
Source dataset
uspto-grants-2003_04
Patent number
US06552057B2

Reaction notes

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