反应详情

To a mixture of 50 g. of 4-hydroxy-4-methyl-oct-1-yn-7-ene and 61.3 g. of imidazole in 100 ml. of dimethylformamide at 0° C., is added, with stirring, 49.1 g. of trimethylsilyloxy chloride. The mixture is stirred at room temperature overnight and poured into petroleum ether and water. The organic layer is washed with water and saturated sodium bicarbonate solution and dried over magnesium sulfate. The solvent is removed and the residue distilled (74°-78° C., 1.5 mm.) to give the product as a colorless liquid.

1. additionTo a mixture of 50 g
2. stirringThe mixture is stirred at room temperature overnight
3. washThe organic layer is washed with water and saturated sodium bicarbonate solution
4. dry with materialdried over magnesium sulfate
5. customThe solvent is removed
6. distillationthe residue distilled (74°-78° C., 1.5 mm.)