1-Methylpiperazine → HCID 10540665, compound

HRID 1267280Notes

Reaction equation

HRID 1267280 reaction equation
[Cl:1][C:2]1[C:3]([CH3:13])=[C:4]([CH3:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:13])=[C:4]([CH3:12])[C:5]2[O:9][C:8]([N:18]3[CH2:19][CH2:20][N:15]([CH3:14])[CH2:16][CH2:17]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178427898HCID 178427898, compound

Product 1

HCID 10540665HCID 10540665, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5-Chloro-6,7-dimethyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylpiperazine (1.54 ml) was added dropwise to the solution and then the mixture was stirred with heating for 29 hours. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5-chloro-6,7-dimethyl-2-(4-methyl-1-piperazinyl)benzoxazole (260 mg).

Workup

  1. temperaturewith heating for 29 hours
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

Sources & evidence

ORD record
ord-bfa24dcd26d04d7cb880e13f07d13801
Source dataset
uspto-grants-2003_04
Patent number
US06552057B2

Reaction notes

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