1-Methylpiperazine → HCID 10804130, compound

HRID 1267281Notes

Reaction equation

HRID 1267281 reaction equation
[Cl:1][C:2]1[C:3]([CH3:13])=[C:4]([Cl:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:13])=[C:4]([Cl:12])[C:5]2[O:9][C:8]([N:18]3[CH2:19][CH2:20][N:15]([CH3:14])[CH2:16][CH2:17]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178427899HCID 178427899, compound

Product 1

HCID 10804130HCID 10804130, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5,7-Dichloro-6-methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylpiperazine (0.94 ml) was added dropwise to the solution and then the mixture was stirred with heating for 29 hours. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5,7-dichloro-6-methyl-2-(4-methyl-1-piperazinyl)benzoxazole (163 mg).

Workup

  1. temperaturewith heating for 29 hours
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

Sources & evidence

ORD record
ord-a9859d023a4042e8b3d0c4beab10bf73
Source dataset
uspto-grants-2003_04
Patent number
US06552057B2

Reaction notes

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