反应详情

A solution of 25 g (110 mmol) 4-benzoylbenzoic acid [611-95-0] and 20 mL SOCl2 was allowed to reflux for 2 h then allowed to cool. The excess SOCl2 was evaporated off and the resulting clear oil was dissolved in 10 mL CH2Cl2 then slowly added to 12 mL (116 mmol) diethylamine in a mixture of 10 mL 3N NaOH and 50 mL CH2Cl2. The mixture was allowed to stir for 30 min then partitioned between H2O and CH2Cl2. The organic layer was washed with brine, dried over K2CO3, filtered and concentrated. The product precipitated from EtOAc/hexane to give 29.6 g (105 mmol) white crystals. MS m/z (MH+) 282.

1. temperatureto reflux for 2 h
2. temperatureto cool
3. customThe excess SOCl2 was evaporated off
4. dissolutionthe resulting clear oil was dissolved in 10 mL CH2Cl2
5. customthen partitioned between H2O and CH2Cl2
6. washThe organic layer was washed with brine
7. dry with materialdried over K2CO3
8. filtrationfiltered
9. concentrationconcentrated
10. customThe product precipitated from EtOAc/hexane