HCID 54378998, compound → HCID 54526015, compound

HRID 1267604Notes

Reaction equation

HRID 1267604 reaction equation
C([N:8]1[CH2:16][C:15](=[N:17][O:18][CH3:19])[C:10]2([CH2:13][N:12]([CH3:14])[CH2:11]2)[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:19][O:18][N:17]=[C:15]1[C:10]2([CH2:11][N:12]([CH3:14])[CH2:13]2)[CH2:9][NH:8][CH2:16]1

Participants

5

Reactant 2

HCID 54378998HCID 54378998, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54526015HCID 54526015, compoundYield 87.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

340 mg of 6-benzyl-8-(methoxyimino)-2-methyl-2,6-diazaspiro[3,4]octane was dissolved in 10 ml of methanol and thereto 300 mg of 10% Pd-C was added. The resulting mixture was stirred for 2 hours at 50° C. under the pressure of hydrogen, filtered and concentrated under the reduced pressure to give 195 mg of the titled compound (yield: 85.2%).

Workup

  1. filtrationfiltered
  2. concentrationconcentrated under the reduced pressure

Sources & evidence

ORD record
ord-7af78abc1d1b48f0bec0f3a7594e0864
Source dataset
uspto-grants-2003_04
Patent number
US06552196B2

Reaction notes

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