Hydrogen Bromide → HCID 20287958, compound

Participants

Reaction Steps

A mixture of 3-(4-methoxyphenyl)-6-n-butylamino-tetrahydro-1,3,5-triazine-2,4-dione (1.0 g.) and hydrobromic acid (48% w/v; 20 ml.) was heated under reflux for 16 hours. The mixture was cooled to room temperature, diluted with water (100 ml.), and the aqueous solution adjusted to pH 6-7 by addition of aqueous sodium hydroxide solution. The white solid produced was separated by filtration, washed with water (3×70 ml.) and dried (over phosphorus pentoxide) to give 3-(4-hydroxyphenyl)-6-n-butylamino-tetrahydro-1,3,5-triazine-2,4-dione (0.5 g., 63%), m.p. 263°-265° C.

Provenance & Evidence