Hydrogen Bromide → HCID 20287958, compound

HRID 126761Notes

Reaction equation

HRID 126761 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[NH:13][CH:12]([NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[NH:11][C:10]2=[O:21])=[CH:5][CH:4]=1.Br.[OH-].[Na+]>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:10](=[O:21])[NH:11][CH:12]([NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[NH:13][C:14]2=[O:15])=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 20287946HCID 20287946, compound

Product 1

HCID 20287958HCID 20287958, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-(4-methoxyphenyl)-6-n-butylamino-tetrahydro-1,3,5-triazine-2,4-dione (1.0 g.) and hydrobromic acid (48% w/v; 20 ml.) was heated under reflux for 16 hours. The mixture was cooled to room temperature, diluted with water (100 ml.), and the aqueous solution adjusted to pH 6-7 by addition of aqueous sodium hydroxide solution. The white solid produced was separated by filtration, washed with water (3×70 ml.) and dried (over phosphorus pentoxide) to give 3-(4-hydroxyphenyl)-6-n-butylamino-tetrahydro-1,3,5-triazine-2,4-dione (0.5 g., 63%), m.p. 263°-265° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. customThe white solid produced
  4. customwas separated by filtration
  5. washwashed with water (3×70 ml.)
  6. dry with materialdried (over phosphorus pentoxide)

Sources & evidence

ORD record
ord-70f98b47c7c24cca8671d00fb75710e4
Source dataset
uspto-grants-1981_03
Patent number
US04254122

Reaction notes

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