反应详情

温度

50 °C

1-(2,4-difluorophenyl)-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and 120 mg of t-butyl 8-(methoxyimino)-2,6-diazaspiro[3,4]octane-2-carboxylate were added to 10 ml of acetonitrile and thereto 0.5 ml of triethylamine was added dropwise. The resulting mixture was stirred for 4 hours at 50° C. and then for 2 hours at the room temperature. The precipitated solid was filtered and dried to give 150 mg of the titled compound (yield: 79.9%).

1. waitfor 2 hours at the room temperature
2. filtrationThe precipitated solid was filtered
3. customdried