Ethyl 5-chloronicotinate → Ethyl 5-(3,4,5-trimethoxyphenyl)nicotinate

HRID 1267639Notes

Reaction equation

HRID 1267639 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].Cl[C:17]1[CH:18]=[N:19][CH:20]=[C:21]([CH:27]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:17]2[CH:18]=[N:19][CH:20]=[C:21]([CH:27]=2)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 210009Ethyl 5-chloronicotinateHCID 27343903,4,5-Trimethoxybenzeneboronic acid

Product 1

HCID 22557861Ethyl 5-(3,4,5-trimethoxyphenyl)nicotinate

Procedure

3,4,5-Trimethoxyphenylboronic acid (6.36 g) and ethyl 5-chloronicotinate (6.90 g) were reacted in the same manner as in Preparation Example 1 to obtain the title compound.

Sources & evidence

ORD record
ord-5501bd2d582e4b7f9c86c14a7aadf539
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

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