1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazine → Hydrochloric Acid

HRID 1267644Notes

Reaction equation

HRID 1267644 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[Cl:26][CH2:27][C:28]1[CH:33]=[CH:32][N:31]=[C:30]([C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:35]=2)[CH:29]=1>>[ClH:26].[ClH:26].[ClH:26].[ClH:26].[CH:35]1[C:36]2[C:41](=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:42]=[CH:43][C:34]=1[C:30]1[CH:29]=[C:28]([CH2:27][N:23]2[CH2:24][CH2:25][N:20]([CH2:19][C:17]3[CH:16]=[CH:15][N:14]=[C:13]([C:5]4[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:18]=3)[CH2:21][CH2:22]2)[CH:33]=[CH:32][N:31]=1.[ClH:26]

Participants

4

Reactant 2

HCID 120211551-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazineHCID 18546863HCID 18546863, compound

Product 2

HCID 313Hydrochloric AcidHCID 18546817HCID 18546817, compound

Procedure

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazine (69 mg) and 4-chloromethyl-2-(2-naphthyl)pyridine (56 mg) were reacted in the same manner as in Example 1 to obtain the title compound in the form of a hydrochloride.

Sources & evidence

ORD record
ord-68c1ddae972148b78f4f5cb297794274
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

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