4-Methoxyphenylacetyl chloride → Hydrochloric Acid

HRID 1267659Notes

Reaction equation

HRID 1267659 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][C:35]([Cl:37])=[O:36])=[CH:30][CH:29]=1>>[ClH:37].[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][C:35]([N:23]2[CH2:24][CH2:25][N:20]([CH2:19][C:17]3[CH:16]=[CH:15][N:14]=[C:13]([C:5]4[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:18]=3)[CH2:21][CH2:22]2)=[O:36])=[CH:30][CH:29]=1.[ClH:37]

Participants

4

Reactant 2

HCID 27346884-Methoxyphenylacetyl chlorideHCID 120211551-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazine

Product 2

HCID 313Hydrochloric AcidHCID 18546848HCID 18546848, compound

Procedure

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) and (4-methoxyphenyl)acetyl chloride (60 mg) were reacted in the same manner as in Example 46 to obtain the title compound in the form of a hydrochloride.

Sources & evidence

ORD record
ord-d11439db855a44f6ac1a2b1127fb3941
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

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