4-Nitrobenzoyl chloride → N-(4-nitrobenzoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazine

HRID 1267663Notes

Reaction equation

HRID 1267663 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[N+:26]([C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1)([O-:28])=[O:27]>>[N+:26]([C:29]1[CH:30]=[CH:31][C:32]([C:33]([N:23]2[CH2:24][CH2:25][N:20]([CH2:19][C:17]3[CH:16]=[CH:15][N:14]=[C:13]([C:5]4[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:18]=3)[CH2:21][CH2:22]2)=[O:34])=[CH:36][CH:37]=1)([O-:28])=[O:27]

Participants

3

Reactant 2

HCID 85024-Nitrobenzoyl chlorideHCID 120211551-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazine

Product 1

HCID 18546812N-(4-nitrobenzoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazine

Procedure

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) and 4-nitrobenzoyl chloride (72 mg) were reacted in the same manner as in Example 46 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-1fcc9b34be07427897cca05ce355ef26
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

Loading…