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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1267663Generated: November 1, 2026

4-Nitrobenzoyl chloride → N-(4-nitrobenzoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazine

https://huagongshe.com/reaction/1267663

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Nitrobenzoyl chlorideHCID 8502—
Reactant1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazineHCID 12021155—
ProductN-(4-nitrobenzoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazineHCID 18546812—

Reaction Steps

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) and 4-nitrobenzoyl chloride (72 mg) were reacted in the same manner as in Example 46 to obtain the title compound as a free base.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06552188B2
Source datasetuspto-grants-2003_04
ORD IDord-1fcc9b34be07427897cca05ce355ef26
Source noteuspto-grants-2003_04