3-(3,4,5-Trimethoxyphenyl)acrylic acid → N-(3,4,5-trimethoxycinnamoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazine
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:36]=[C:37]([O:41][CH3:42])[C:38]=1[O:39][CH3:40])[CH:31]=[CH:32][C:33](O)=[O:34]>>[CH3:42][O:41][C:37]1[CH:36]=[C:30]([CH:29]=[C:28]([O:27][CH3:26])[C:38]=1[O:39][CH3:40])[CH:31]=[CH:32][C:33]([N:23]1[CH2:24][CH2:25][N:20]([CH2:19][C:17]2[CH:16]=[CH:15][N:14]=[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=2)[CH2:21][CH2:22]1)=[O:34]Participants
3
Procedure
1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) and 3,4,5-trimethoxycinnamic acid (65 mg) were reacted in the same manner as in Example 56 to obtain the title compound as a free base.
Sources & evidence
- ORD record
- ord-ed81225b5b9c41218ed7e369410c4c1e
- Source dataset
- uspto-grants-2003_04
- Patent number
- US06552188B2
Reaction notes
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