N-Acetyl-DL-methionine → L-Methionine

Participants

Reaction Conditions

Reaction Steps

A mixture of 19.1 grams (g) of N-acetyl-D,L-methionine and 150 milliliters (ml) of water was heated for 1 hour at 180° C. in a laboratory autoclave. After cooling to room temperature, 6.1 g of crystalline methionine (content, determined by HPLC: 99.7%) were obtained. A further 5.9 g of methionine and 3.4 g of acetyl-methionine were contained in the filtrate. The conversion of the acetyl compound was 82.2%, the selectivity of the reaction was 97.8%.

Provenance & Evidence