N-Acetyl-DL-methionine → L-Methionine
Reaction equation
C([NH:4][CH:5]([C:10]([OH:12])=[O:11])[CH2:6][CH2:7][S:8][CH3:9])(=O)C>O>[NH2:4][C@H:5]([C:10]([OH:12])=[O:11])[CH2:6][CH2:7][S:8][CH3:9]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 180 °C
Procedure
A mixture of 19.1 grams (g) of N-acetyl-D,L-methionine and 150 milliliters (ml) of water was heated for 1 hour at 180° C. in a laboratory autoclave. After cooling to room temperature, 6.1 g of crystalline methionine (content, determined by HPLC: 99.7%) were obtained. A further 5.9 g of methionine and 3.4 g of acetyl-methionine were contained in the filtrate. The conversion of the acetyl compound was 82.2%, the selectivity of the reaction was 97.8%.
Workup
- temperatureAfter cooling to room temperature
Sources & evidence
- ORD record
- ord-256686a159f44c9f8233b77b2292c0d0
- Source dataset
- uspto-grants-2003_04
- Patent number
- US06552222B2
Reaction notes
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