1-Carbethoxycarbonylmethyl-2-amino-3-carbamoyl-quinoxalinium bromide → Ethyl 4-carbamoyl-imidazo-[1,2-a]-quinoxaline-2-carboxylate

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Reaction Steps

A suspension of 1 g of the product of Step A in 100 ml of ethanol was refluxed with stirring for 90 minutes and the resulting yellow solution was concentrated and cooled. The mixture was filtered to obtain 0.55 g of ethyl 4-carbamoyl-imidazo-[1,2-a]-quinoxaline-2-carboxylate as a pale yellow crystalline solid. Recrystallization from ethanol yielded soft white needles melting at 280°-284° C.

Provenance & Evidence