Ethyl 2-(7,7,8,8,8-pentafluorooctyl)-9-decenoate → 11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)undecanoic acid

HRID 1267762Notes

Reaction equation

HRID 1267762 reaction equation
[CH2:1]([C:3]1([C:39]2[CH:44]=[CH:43][C:42]([OH:45])=[CH:41][CH:40]=2)[CH:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]C(CCCCCCC(F)(F)C(F)(F)F)C(O)=O)[C:11]2[C:6](=[CH:7][C:8]([OH:38])=[CH:9][CH:10]=2)[S:5][CH2:4]1)[CH3:2].[F:46][C:47]([F:72])([C:68]([F:71])([F:70])[F:69])[CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH:54]([CH2:60]CCCCCC=C)[C:55]([O:57]CC)=[O:56]>>[CH2:1]([C:3]1([C:39]2[CH:40]=[CH:41][C:42]([OH:45])=[CH:43][CH:44]=2)[CH:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:60][CH:54]([CH2:53][CH2:52][CH2:51][CH2:50][CH2:49][CH2:48][C:47]([F:46])([F:72])[C:68]([F:71])([F:70])[F:69])[C:55]([OH:57])=[O:56])[C:11]2[C:6](=[CH:7][C:8]([OH:38])=[CH:9][CH:10]=2)[S:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 18546272Ethyl 2-(7,7,8,8,8-pentafluorooctyl)-9-decenoateHCID 1854627710-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(7,7,8,8,8-pentafluoro-octyl)decanoic acid

Product 1

HCID 1854626711-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)undecanoic acid

Procedure

Starting with the allyl compound prepared in Example 13 and the ethyl 2-(7,7,8,8,8-pentafluorooctyl)-9-decenoate prepared in Example 8, the same procedure as shown in Example 13 was repeated to give 11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)undecanoic acid.

Sources & evidence

ORD record
ord-ac7cd815412744e485122b34a7176d4c
Source dataset
uspto-grants-2003_04
Patent number
US06552068B1

Reaction notes

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