11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)-undecanoic acid → 10-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)decanoic acid

HRID 1267774Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1267774
[CH2:1]([C:3]1([C:40]2[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=2)[CH:12]([CH2:13]CCCCCCCCC(CCCCCCC(F)(F)C(F)(F)F)C(O)=O)[C:11]2[C:6](=[CH:7][C:8]([OH:39])=[CH:9][CH:10]=2)[O:5][CH2:4]1)[CH3:2].[F:47][C:48]([F:72])([C:68]([F:71])([F:70])[F:69])[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH:55]([CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH:66]=[CH2:67])[C:56]([O:58]CC)=[O:57]>>[CH2:1]([C:3]1([C:40]2[CH:41]=[CH:42][C:43]([OH:46])=[CH:44][CH:45]=2)[CH:12]([CH2:13][CH2:67][CH2:66][CH2:65][CH2:64][CH2:63][CH2:62][CH2:61][CH:55]([CH2:54][CH2:53][CH2:52][CH2:51][CH2:50][CH2:49][C:48]([F:47])([F:72])[C:68]([F:69])([F:70])[F:71])[C:56]([OH:58])=[O:57])[C:11]2[C:6](=[CH:7][C:8]([OH:39])=[CH:9][CH:10]=2)[O:5][CH2:4]1)[CH3:2]

Komponenten

3

Edukt 2

HCID 1854626411-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)-undecanoic acidHCID 18546271Ethyl 2-(7,7,8,8,8-pentafluorooctyl)-8-nonenoate

Produkt 1

HCID 1854625310-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)decanoic acid

Versuchsvorschrift

Starting with the allyl compound prepared in Example 21 and the ethyl 2-(7,7,8,8,8-pentafluorooctyl)-8-nonenoate prepared in Example 12, the same procedure as shown in Example 21 was repeated to give 10-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)decanoic acid.

Quellen und Nachweise

ORD-Eintrag
ord-f4df6410459f44b68f94e7ba573c7f1f
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06552068B1

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