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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1267774Generated: October 25, 2026

11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)-undecanoic acid → 10-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)decanoic acid

https://huagongshe.com/reaction/1267774

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)-undecanoic acidHCID 18546264—
ReactantEthyl 2-(7,7,8,8,8-pentafluorooctyl)-8-nonenoateHCID 18546271—
Product10-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)decanoic acidHCID 18546253—

Reaction Steps

Starting with the allyl compound prepared in Example 21 and the ethyl 2-(7,7,8,8,8-pentafluorooctyl)-8-nonenoate prepared in Example 12, the same procedure as shown in Example 21 was repeated to give 10-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)chroman-4-yl]-2-(7,7,8,8,8-pentafluorooctyl)decanoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06552068B1
Source datasetuspto-grants-2003_04
ORD IDord-f4df6410459f44b68f94e7ba573c7f1f
Source noteuspto-grants-2003_04