HRID1267788

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCC1(c2ccc(O)cc2)CSc2cc(O)ccc2C1CCCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O

HCID10211406

未命名化合物

结构：C=CCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)OCC

HCID12043786

Ethyl 2-(4,4,5,5,5-pentafluoropentyl)-9-decenoate

C17H27F5O2

PRODUCTS

生成物

结构：CCCC1(c2ccc(O)cc2)CSc2cc(O)ccc2C1CCCCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O

HCID10282995

未命名化合物

PROCEDURE

实验过程

Starting with the allyl compound prepared in Example 29 and ethyl 2-(4,4,5,5,5,-pentafluoropentyl)-9-decenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 11-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(4,4,5,5,5,-pentafluoropentyl)undecanoic acid.

WORKUP

后处理

customprepared separately

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e7ff9321b834cf687237312c1e5f3f0
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06552068B1
来源说明: uspto-grants-2003_04

反应 SMILES

[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:22]CCCCCCCC(CCCC(F)(F)C(F)(F)F)C(O)=O)[C:7]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)([CH2:12][CH2:13][CH3:14])[CH2:8][S:9]2)=[CH:4][CH:3]=1.[F:44][C:45]([F:67])([C:63]([F:66])([F:65])[F:64])[CH2:46][CH2:47][CH2:48][CH:49]([CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH:61]=[CH2:62])[C:50]([O:52]CC)=[O:51]>>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:22][CH2:62][CH2:61][CH2:60][CH2:59][CH2:58][CH2:57][CH2:56][CH2:55][CH:49]([CH2:48][CH2:47][CH2:46][C:45]([F:44])([F:67])[C:63]([F:64])([F:65])[F:66])[C:50]([OH:52])=[O:51])[C:7]([C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)([CH2:12][CH2:13][CH3:14])[CH2:8][S:9]2)=[CH:4][CH:3]=1