反应详情

To a solution of 7.36 g. (0.184 mole) of sodium hydroxide in 75 ml. of water and 75 ml. of acetone there is added 19.02 g. (0.074 mole) of 1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride and 11.59 g. (0.074 mole) of 1-bromo-3-chloropropane, and the resulting mixture is stirred at 27° for 18 hrs. The organic layer is then separated and concentrated to an oil under reduced pressure. The oil is treated with hot (85°) 6 N HCl until solution is complete, and the resulting solution is filtered and stored at 5° for 18 hrs. The precipitate which forms is collected on a filter to afford 14.73 g. (66%) of the hydrochloride salt of the product, m.p. 190°-192°.

1. customThe organic layer is then separated
2. concentrationconcentrated to an oil under reduced pressure
3. additionThe oil is treated with hot (85°) 6 N HCl until solution
4. filtrationthe resulting solution is filtered
5. customThe precipitate which forms is collected on
6. filtrationa filter
7. customto afford 14.73 g