Hydrochloric Acid → 5-amino-6-bromo-1-indanone

HRID 1267808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1267808
C([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[C:10](=[O:15])[CH2:9][CH2:8]2)(=O)C.Cl>[OH-].[Na+]>[NH2:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[C:10](=[O:15])[CH2:9][CH2:8]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 9993147N-(6-Bromo-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

Produkt 1

HCID 103987765-amino-6-bromo-1-indanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 5-acetylamino-6-bromo-1-indanone (36.0 g, 0.13 mol) and 6M aqueous hydrochloric acid (800 mL) was refluxed for 1 h. The homogenous solution was then cooled to 0° C. and adjusted to pH 8 with 10M aqueous NaOH (−480 mL). The precipitate formed was collected, washed with water and dried under vacuum to afford 30.0 g (quantitative) of the title compound as a light brown powder. 1H NMR (acetone-d6): δ7.65 (1H, s), 6.90 (1H, s), 5.80 (2H, br s), 2.95 (2H, t), 2.50 (2H, t).

Aufarbeitung

  1. temperaturewas refluxed for 1 h
  2. customThe precipitate formed
  3. customwas collected
  4. washwashed with water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-be21fa1ab6274eaeb9d8410fc9e3aa31
Quelldatensatz
uspto-grants-2003_04
Patentnummer
USRE038103E1

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