HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → H-Phe-Met-OMe.HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | tert-Butoxycarbonyl-phenylalanyl-methionine methyl ester | HCID 8022451 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | H-Phe-Met-OMe.HCl | HCID 67685067 | — |
Reaction Steps
To an ice cold solution of 16.42 g of Boc-Phe-Met-OCH3 and 21.7 ml of anisole in 200 ml of EtOAc was introduced hydrogen chloride for 30 min. Evaporation of the solution gave a residue which was dissolved in 100 ml of EtOAc and diluted with 400 ml of hexane to give H-Phe-Met-OCH3.HCl which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04254024 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-dae1a4c4532a49828fb65d87d2f9eabb |
| Source note | uspto-grants-1981_03 |