p-Toluenesulfonic acid monohydrate → HCID 18543923, compound

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A mixture of 4-hydroxy-1-[4-(methylthio)phenyl]-2-[2-(phenyl)-1,3,4-thiadiazol-5-yl]-4-(trifluoromethyl)-4,5-dihydro-1H-imidazole (0.5 g, 1.15 mmol) and p-toluenesulfonic acid monohydrate (30 mg) in toluene (50 mL) was heated to reflux for 1 hour. After aqueous work up, 1-[4-(Methylthio)phenyl]-2-[2-(phenyl)-1,3,4-thiadiazol-5-yl]-4-(trifluoromethyl)-imidazole was isolated as a white solid.

Provenance & Evidence