p-Toluenesulfonic acid monohydrate → HCID 18543923, compound

HRID 1268063Notes

Reaction equation

HRID 1268063 reaction equation
O[C:2]1([C:26]([F:29])([F:28])[F:27])[CH2:6][N:5]([C:7]2[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=2)[C:4]([C:15]2[S:19][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:17][N:16]=2)=[N:3]1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:14][S:13][C:10]1[CH:9]=[CH:8][C:7]([N:5]2[CH:6]=[C:2]([C:26]([F:28])([F:27])[F:29])[N:3]=[C:4]2[C:15]2[S:19][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:17][N:16]=2)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 18543950HCID 18543950, compound

Product 1

HCID 18543923HCID 18543923, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4-hydroxy-1-[4-(methylthio)phenyl]-2-[2-(phenyl)-1,3,4-thiadiazol-5-yl]-4-(trifluoromethyl)-4,5-dihydro-1H-imidazole (0.5 g, 1.15 mmol) and p-toluenesulfonic acid monohydrate (30 mg) in toluene (50 mL) was heated to reflux for 1 hour. After aqueous work up, 1-[4-(Methylthio)phenyl]-2-[2-(phenyl)-1,3,4-thiadiazol-5-yl]-4-(trifluoromethyl)-imidazole was isolated as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour

Sources & evidence

ORD record
ord-fc0c3b85f8aa4c3890d9726e92901ee6
Source dataset
uspto-grants-2003_04
Patent number
US06555563B1

Reaction notes

Loading…