反应详情

A mixture of 4.75 g. of 5,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine, 1.0 g. of 10% palladium on carbon, and 120 ml. of xylene was stirred and refluxed for 22 hours. After removal of the catalyst, the filtrate was evaporated in vacuo and the residue was purified by chromatography on a Florisil column (150 g.). The column was first eluted with chloroform, followed by 5% methanol in chloroform to give the pure product; m.p. 72°-74°.

1. additionA mixture of 4.75 g
2. temperaturerefluxed for 22 hours
3. customAfter removal of the catalyst
4. customthe filtrate was evaporated in vacuo
5. customthe residue was purified by chromatography on a Florisil column (150 g.)
6. washThe column was first eluted with chloroform
7. customto give the pure product