反应详情

In a stream of nitrogen and under ice-cooling, 210 mg (1.67 mmol) of potassium tert-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.78 mmol) of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, and the mixture was stirred for 1 hour. This solution was mixed with 176 mg (1.19 mmol) of n-hexanoyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 300 mg (yield: 86%) of the title compound.

1. temperatureIn a stream of nitrogen and under ice-cooling
2. customproduced in Reference Example 1
3. stirringstirred at room temperature for 3 hours
4. customAfter completion of the reaction
5. customthe solvent was evaporated
6. extractionThe resulting residue was extracted with ethyl acetate
7. washwashed with water and saturated brine
8. dry with materialdried over anhydrous sodium sulfate
9. customthe solvent was evaporated under a reduced pressure
10. customThe resulting residue was purified by a silica gel column chromatography