HCID 18542565, compound → HCID 18542797, compound

HRID 1268231Notes

Reaction equation

HRID 1268231 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:20]([C:21](=[O:23])[NH2:22])=[CH:19][C:18]([N+:24]([O-])=O)=[CH:17][C:16]=2[C:27](=[O:29])[NH2:28])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[C:16]([C:27](=[O:29])[NH2:28])=[CH:17][C:18]([NH2:24])=[CH:19][C:20]=2[C:21](=[O:23])[NH2:22])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 18542565HCID 18542565, compound

Product 1

HCID 18542797HCID 18542797, compoundYield 100.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-dicarbamoylnitrobenzene (3.0 g) in methanol (60 ml) was added palladium on carbon (0.3 g) and the mixture was stirred under a hydrogen atmosphere at room temperature for 1 hour. The reaction mixture was filtered and the filtrate concentrated in vacuo to give the desired compound (2.8 g, yield quantitative) as a yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-ff839399b7544dae83a6f8756712e942
Source dataset
uspto-grants-2003_04
Patent number
US06555556B1

Reaction notes

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