Diisobutylaluminum hydride → HCID 22557608, compound

HRID 1268288Notes

Reaction equation

C([O:3][C:4](=O)/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[C:17]([CH:19]([CH3:21])[CH3:20])[CH:16]=[CH:15][C:14]=2[O:22][CH3:23])=[CH:9][CH:8]=1)C.CC(C[AlH]CC(C)C)C>>[CH:19]([C:17]1[CH:16]=[CH:15][C:14]([O:22][CH3:23])=[C:13]([C:10]2[CH:11]=[CH:12][C:7](/[CH:6]=[CH:5]/[CH2:4][OH:3])=[CH:8][CH:9]=2)[CH:18]=1)([CH3:21])[CH3:20]

Participants

Reactant 2

HCID 14487Diisobutylaluminum hydride

HCID 69801209HCID 69801209, compound

Product 1

HCID 22557608HCID 22557608, compound

Procedure

(E)-3-(5′-Isopropyl-2′-methoxy-biphenyl-4-yl)-acrylic acid ethyl ester was reduced by DIBAL-H by a procedure analogous to that described in example 52b to give (E)-3-(5′-isopropyl-2′-methoxy-biphenyl-4-yl)-prop-2-en-1-ol.

Sources & evidence

ORD record: ord-8157560c19b844aa8699f0147fb21560
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06555577B1

Reaction notes

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