4-Bromoaniline → 1-(4-Bromophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

HRID 1268372Notes

Reaction equation

HRID 1268372 reaction equation
[C:1]1([C:7]([OH:9])=[O:8])([C:4](O)=[O:5])[CH2:3][CH2:2]1.[Br:10][C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=1>C(#N)C>[Br:10][C:11]1[CH:17]=[CH:16][C:14]([N:15]2[CH2:3][CH2:2][CH:1]([C:7]([OH:9])=[O:8])[C:4]2=[O:5])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 78074-BromoanilineHCID 690171,1-Cyclopropanedicarboxylic acid

Product 1

HCID 35985231-(4-Bromophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

30 g of 1,1-cyclopropanedicarboxylic acid and 50 g of 4-bromoaniline were added to 50 ml of acetonitrile, followed by refluxing for 7 hours with heating and stirring.

Workup

  1. temperatureby refluxing for 7 hours
  2. temperaturewith heating

Sources & evidence

ORD record
ord-8eb52f9df5124485a74cf3eebb8e0392
Source dataset
uspto-grants-2003_04
Patent number
US06555694B1

Reaction notes

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