Ethanol → Ethyl 2-[4-(cyclopropanecarbonyl)phenyl]-2-methylpropanoate

HRID 1268402Notes

Reaction equation

HRID 1268402 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13](N)=[O:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[CH2:18]([OH:20])[CH3:19]>>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([O:20][CH2:18][CH3:19])=[O:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 702EthanolHCID 234998512-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

Product 1

HCID 9813859Ethyl 2-[4-(cyclopropanecarbonyl)phenyl]-2-methylpropanoate

Procedure

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionamide (100 mg) in ethanol and bubble in hydrochloride gas for 5 minutes while stirring. Reflux for 10 hours, distill off the ethanol and extract into ethyl acetate. Evaporate the solvent in vacuo to give the title compound as an oil (50 mg).

Workup

  1. custombubble in hydrochloride gas for 5 minutes
  2. temperatureReflux for 10 hours
  3. distillationdistill off the ethanol
  4. extractionextract into ethyl acetate
  5. customEvaporate the solvent in vacuo

Sources & evidence

ORD record
ord-89c6508aa28a4737b02b6b676299f8fb
Source dataset
uspto-grants-2003_04
Patent number
US06555689B2

Reaction notes

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