反应详情

N-Methyl-N-((R)1-(methylcarbamoyl)-2-phenylethyl)carbamic acid tert-butyl ester (1.39 g, 7.23 mmol) was dissolved in a mixture of trifluoroacetic acid (5 mL) and methylene chloride (10 mL) and stirred for 45 min. The volatiles were removed in vacuo and the residue was stirred with a mixture of ethyl acetate (100 mL) and water (100 mL). Sodium hydrogen carbonate (50 mL, saturated) was added and the phases were separated. The organic phase was dried (magnesium sulfate) and the solvent removed in vacuo to afford 330 mg of (R)-N-methyl-2-methylamino-3-phenylpropionamide.

1. customThe volatiles were removed in vacuo
2. stirringthe residue was stirred with a mixture of ethyl acetate (100 mL) and water (100 mL)
3. additionSodium hydrogen carbonate (50 mL, saturated) was added
4. customthe phases were separated
5. dry with materialThe organic phase was dried (magnesium sulfate)
6. customthe solvent removed in vacuo