Thionyl Chloride → 1-Acetyl-4-piperidineacetyl chloride

HRID 126858Notes

Reaction equation

S(Cl)([Cl:3])=O.[C:5]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:17])=O)[CH2:10][CH2:9]1)(=[O:7])[CH3:6]>>[C:5]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([Cl:3])=[O:17])[CH2:10][CH2:9]1)(=[O:7])[CH3:6]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 10442408(1-Acetylpiperidin-4-yl)acetic acid

Product 1

HCID 202880651-Acetyl-4-piperidineacetyl chlorideYield 95%

Procedure

To 240 parts of thionyl chloride are added portionwise 25 parts of 1-acetyl-4-piperidineacetic acid and the whole is stirred overnight at room temperature. The reaction mixture is evaporated, yielding 26.5 parts (95%) of 1-acetyl-4-piperidineacetyl chloride as an oily residue.

Workup

customThe reaction mixture is evaporated

Sources & evidence

ORD record: ord-6d0ab50928a64ba0a9220c1c4b1ab58e
Source dataset: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04254127

Reaction notes

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