反应详情

To a stirred mixture of 50 parts of fluorobenzene and 32 parts of aluminium trichloride is added dropwise (slowly) a solution of 26.5 parts of 1-acetyl-4-piperidineacetyl chloride in 50 parts of fluorobenzene. Upon completion, stirring is continued for 2 hours at reflux temperature. The reaction mixture is cooled to room temperature and poured onto a mixture of crushed ice and a hydrochloric acid solution. The aqueous phase is separated and extracted with methylbenzene. The combined organic phases are dried, filtered and evaporated, yielding 31 parts (90%) of 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone as a residue.

1. temperatureat reflux temperature
2. additionpoured onto a mixture of crushed ice
3. customThe aqueous phase is separated
4. extractionextracted with methylbenzene
5. customThe combined organic phases are dried
6. filtrationfiltered
7. customevaporated