Hydrochloric Acid → HCID 20288060, compound

HRID 126860Notes

Reaction equation

HRID 126860 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[O:12])[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11](=[O:12])[CH2:10][CH:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 202880291-Acetyl-4-[2-(4-methoxyphenyl)-2-oxoethyl]piperidine

Product 1

HCID 20288060HCID 20288060, compoundYield 59%

Conditions

Temperature
100 °C

Procedure

A mixture of 10 parts of 1-acetyl-4-[2-(4-methoxyphenyl)-2-oxoethyl]piperidine and 50 parts of a hydrochloric acid solution 6 N is stirred and heated for 4 hours at 100° C. The reaction mixture is allowed to cool to room temperature. The precipitated product is filtered off and crystallized from 2-propanol, yielding 5.8 parts (59%) of 1-(4-methoxyphenyl)-2-(4-piperidinyl)ethanone hydrochloride; mp. 250.7° C.

Workup

  1. temperatureto cool to room temperature
  2. filtrationThe precipitated product is filtered off
  3. customcrystallized from 2-propanol

Sources & evidence

ORD record
ord-f834473bed7e446cbf91ca0d20b20a1a
Source dataset
uspto-grants-1981_03
Patent number
US04254127

Reaction notes

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