反应详情

温度

100 °C

A mixture of 10 parts of 1-acetyl-4-[2-(4-methoxyphenyl)-2-oxoethyl]piperidine and 50 parts of a hydrochloric acid solution 6 N is stirred and heated for 4 hours at 100° C. The reaction mixture is allowed to cool to room temperature. The precipitated product is filtered off and crystallized from 2-propanol, yielding 5.8 parts (59%) of 1-(4-methoxyphenyl)-2-(4-piperidinyl)ethanone hydrochloride; mp. 250.7° C.

1. temperatureto cool to room temperature
2. filtrationThe precipitated product is filtered off
3. customcrystallized from 2-propanol