反应详情

温度

5 °C

N-((1R)-1-Carbamoyl-2-phenylethyl)-N-methylcarbamic acid tert.-butylester (2.73 g, 9.81 mmol) was dissolved in tetrahydrofuran (10 ml). The solution was cooled to 5° C. A suspension of sodium borohydride (816 mg, 21.58 mmol) in tetrahydrofuran (10 ml) was added. A solution of iodine (1.24 g, 4.91 mmol) was added dropwise. After the addition was completed, the solution was heated to reflux for 16 h. It was cooled to 5° C. A 10% solution of ammonium chloride in water (60 ml) was added dropwise. The solution was warmed to 50° C. for 1 h. It was cooled to room temperature. 1 N sodium hydroxide solution was added until pH 14. It was extracted with tert-butyl methyl ether (4×100 ml). The combined organic layers were dried over magnesium sulfate. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (150 g) using dichloromethane/methanol/25% aqueous ammonia 100:10:1 as eluent to give 453 mg of N-((1R)-1-aminomethyl-2-phenylethyl)-N-methylcarbamic acid tert-butylester.

1. additionwas added
2. additionAfter the addition
3. temperaturethe solution was heated
4. temperatureto reflux for 16 h
5. temperatureIt was cooled to 5° C
6. temperatureThe solution was warmed to 50° C. for 1 h
7. temperatureIt was cooled to room temperature
8. extractionIt was extracted with tert-butyl methyl ether (4×100 ml)
9. dry with materialThe combined organic layers were dried over magnesium sulfate
10. customThe solvent was removed in vacuo
11. customThe crude product was purified by flash chromatography on silica (150 g)