Hydrogen Bromide → HCID 20288063, compound

Participants

Reaction Steps

A mixture of 19 parts of ethyl 4-[2-(3-chlorophenyl)-2-oxoethyl]-1-piperidinecarboxylate and 120 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 2 hours. The reaction mixture is evaporated and the solid residue is boiled in 2-propanol. The product is filtered off after cooling, washed with 2-propanol and dried in vacuo, yielding 17.5 parts (90%) of 1-(3-chlorophenyl)-2-(4-piperidinyl)ethanone hydrobromide; mp. 214.1° C.

Provenance & Evidence