Hydrogen Bromide → HCID 20288063, compound

HRID 126864Notes

Reaction equation

HRID 126864 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:21])[CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OCC)=O)[CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[BrH:22]>O>[BrH:22].[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:21])[CH2:9][CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 20288070HCID 20288070, compound

Product 1

HCID 20288063HCID 20288063, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 19 parts of ethyl 4-[2-(3-chlorophenyl)-2-oxoethyl]-1-piperidinecarboxylate and 120 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 2 hours. The reaction mixture is evaporated and the solid residue is boiled in 2-propanol. The product is filtered off after cooling, washed with 2-propanol and dried in vacuo, yielding 17.5 parts (90%) of 1-(3-chlorophenyl)-2-(4-piperidinyl)ethanone hydrobromide; mp. 214.1° C.

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe reaction mixture is evaporated
  3. filtrationThe product is filtered off
  4. temperatureafter cooling
  5. washwashed with 2-propanol
  6. customdried in vacuo

Sources & evidence

ORD record
ord-2575198f301f40ba9ecaf4ff6b47ffaf
Source dataset
uspto-grants-1981_03
Patent number
US04254127

Reaction notes

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