HCID 20288011, compound → HCID 20288068, compound

HRID 126867Notes

Reaction equation

HRID 126867 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][C:15]3[CH2:16][CH2:17][N:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:19][CH:20]=3)[O:13][CH2:12][CH2:11][O:10]2)[CH:6]=[CH:7][CH:8]=1.[H][H]>[Pt].CC1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][CH:15]3[CH2:20][CH2:19][N:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:17][CH2:16]3)[O:13][CH2:12][CH2:11][O:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 20288011HCID 20288011, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20288068HCID 20288068, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 1140TolueneSolvent

Procedure

A mixture of 30 parts of ethyl 2,3-dihydro-4-[2-(3-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-1(6H)-pyridinecarboxylate and 450 parts of methylbenzene is hydrogenated at normal pressure and at room temperature with 4 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated, yielding 30 parts of ethyl 4-[2-(3-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-1-piperidinecarboxylate as a residue.

Workup

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-95ab9052766f4312b6cc07798f175156
Source dataset
uspto-grants-1981_03
Patent number
US04254127

Reaction notes

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